Novel effect of acetyl-11-keto-boswellic acid (AKBA) on mitophagy-induced apoptosis using cellular proteomic profiling
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic study of 11-Keto -Boswellic Acid
Introduction: Boswellia serrata has been used in traditional medicine for treatment of inflammatory diseases since antiquity. However human kinetic studies are lacking for this. Hence to better elucidate its effects in humans and determine its optimal dosing, this study was planned. Material and Methods: Twelve healthy adult men volunteers were given capsule Wok Vel containing 333 mg of Boswel...
متن کاملComparison Between HPLC and HPTLC Densitometry for the Determination of 11-keto-β-boswellic acid and 3- acetyl-11-keto-β-boswellic acid from Boswellia serrata Extract
Objective: Boswellic acids (BAs) are active constituents of plant Boswellia serrata. In the present study boswellic acids were extracted from Boswellia serrata and dry methanolic extracts were quantified by HPLC and HPTLC. Method: A gradient HPLC method was used for the quantification of the boswellic acids; 11-keto-β-boswellic acid (KBA) and 3acetyl-11-keto-β-boswellic acid (AKBA). A direct HP...
متن کاملSafety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)).
The novel anti-inflammatory properties of the gum resin derived from Boswellia serrata, also known as Salai guggal in Ayurvedic medicine, are well recognized and highly recommended for human consumption. The active constituents of the gum resin are boswellic acids (BAs). Among the BAs, AKBA potently inhibits 5-lipoxygenase product formation with an IC(50) of 1.5 m muM. We developed a novel Bosw...
متن کاملAnalgesic activity of acetyl-11-keto-beta-boswellic acid, a 5-lipoxygenase-enzyme inhibitor
Acetyl-11-keto-beta-boswellic acid (AKBA) is one of the four major pentacyclic triterpenic acids present in the acidic extract of the Boswellia serrata gum resin that is used for a variety of inflammatory disorders, such as rheumatoid arthritis, osteoarthritis, and cervical spondylosis. AKBA is a novel, highly specific inhibitor of 5-lipoxygenase, the key enzyme for leukotriene biosynthesis. It...
متن کاملAcetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I.
Antiproliferative action of different pentacyclic triterpenes has repeatedly been reported, and some lipoxygenase inhibitors have been shown to induce cell death in various cell systems. Acetyl-11-keto-beta-boswellic acid (AKBA) is a pentacyclic triterpene that inhibits 5-lipoxygenase in a selective, enzymedirected, nonredox, and noncompetitive manner. To investigate a possible effect of AKBA o...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2018
ISSN: 0923-7534
DOI: 10.1093/annonc/mdy047.040